Development of an integrated SPECT/MRI system for enhanced stratification of brain tumour patients prior to patient-specific radio-chemo therapy and early assessment of treatment efficacy



ABOUT INSERT

INSERT is a research project funded by the Seventh Framework Programme of the European Commission.

Its acronym (INSERT) stands for “Development of an integrated SPECT/MRI system for enhanced stratification of brain tumour patients prior to patient-specific radio-chemo therapy and early assessment of treatment efficacy”)

The objective of the INSERT project is in fact to develop an innovative system combining SPECT (Single Photon Emission Computed Tomography) and MRI (Magnetic Resonance Imaging), which will enable the simultaneous acquisition of images resulting from the two systems.

The motivation of the INSERT project lays in the high mortality rate of patients with recurrent glioma (a tumour of the central nervous system).

Unfortunately, notwithstanding the innovations brought by the scientific research, the management of these patients, both adults and in paediatric age, is still a challenge, since the life expectancy of these patients is very low and the surgery does not represent a definitive solution in all cases, given to the nature of these tumours.

Thanks to the possibility of obtaining multiple parameters, the INSERT system will enable to better define the tumour biology and to give relevant information for a personalized treatment, with a considerable impact on the efficacy of the treatment itself.

The system will be validated at the pre-clinical level thanks to the creation of animal models, and to the clinical level, thanks to a pilot study which will involve patients with glioma.

The project officially started on March 1st, 2013 and it will last for 4 years.